Endocrine Abstracts

Male infertility is a worldwide healthcare issue, which has driven developed countries to take the necessary steps in detecting and treating the problem. While transition countries such as North Macedonia and most of the surrounding states belonging to the Western Balkans, usually blame the female partner for infertility, thus male factor is underestimated. The term ‘milieu intérieur’ means also a perfect equilibrium between reactive oxygen species (ROS) and a...

Introduction: Acute pancreatitis may cause endocrine and exocrine dysfunction, but in the early phase of acute pancreatitis these changes are poorly documented.Aim: The aim of this study was to asses the endocrine and exocrine impairment in the early phase of AP and to establish the need forPatients and methods: We have collected data from 116 patients with AP, with different aetiologies and degrees of severity of the disease. We h...

Objective: Interleukin-6 (IL-6) is an immunoregulative proinflammatory cytokine with pleiotropic functions. It was reported that plasma level of IL-6 in type 1 diabetes mellitus (T1DM) patients was higher than in healthy individuals. IL-6 is supposed to take part in pancreatic beta-cells destruction. So, we considered IL-6 gene to be a candidate one for T1DM. The aim of present study was to investigate the role of IL-6 gene promoter polymorphism in T1DM developme...

Introduction: Topical diagnosis of insulinoma is an actual problem due to the low detection rate of tumors (about 75%) and conflicting data about its localization in pancreas (more than 50%) when using different imaging techniques. This is partly due to the subjectivity of visualizing diagnosis specialists when describing the location of tumor. We assumed that multimodal imaging Fusion will improve the accuracy of topical diagnosis of insulinoma.Aim: To ...

The Sars-COV-2 virus is a recognized endocrine disruptor, which determines the possibility of endocrine dysfunctions associated with COVID 19. One of the endocrine diseases associated with COVID 19 is subacute thyroiditis (STh), which develops regardless of the severity of manifestations of the underlying disease. The aim of the study: to evaluate the clinical manifestations, therapy, and outcomes of STh in unvaccinated COVID 19 patients.Materials and me...

Aim of the study: To examine the influence of sitagliptin in patients treated with a diabetic diet and metformin, on metabolic parameters and kidney function after three months of sitagliptin therapy.Subjects and methods: 35 patients (19 men and 16 women) were included in the study. Sitagliptin was introduced in patients on a diabetic diet and metformin with HbA1c≥6.5%. Fasting and postprandial plasma glucose value, HbA1c, cholesterol, HDL, LDL, tr...

Aim of the study: The main objectives were to determine incidence and type of anemia in patients with type 2 diabetes and the differences considering gender, age and duration of type 2 diabetes.Material and methods: The research was structured as a cross-sectional research with historical data. The research used data collected during regular check-ups in primary health care clinics in the Osijek Health Center, Croatia, from April to June 2023. Collected ...

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

Objective: Subclinical hypothyroidism (ScH) is a common condition and may be associated with dyslipidemia. We investigated the effect of levothyroxine therapy (L-T4) on lipid parameters in patients with a mild form of subclinical hypothyroidism according to the presence of thyroid peroxidase antibodies (anti-TPO antibodies). Material and methods: Fifty-seven patients with newly diagnosed ScH (TSH levels between upper reference value and 10 mIU/l with nor...

Introduction: There is no doubt that continuous monitoring systems can improve diabetes control. The aim of the study was to determine typical deviations of glucose and mistakes in insulin treatment, self-control, predisposing to the poor blood control.Materials and methods: 30 patients with type 1 diabetes were included, mean age 21±7.8, mean age of diabetes manifestation 19.2±13.9 years, mean duration oа diabetes – 15.3±7.5. Inc...